Name: CDP Choline (Citicoline Sodium, CAS 33818-15-4)
Brand: Keep Ingredients - proteins, extracts, powders
Rating: 5 (1 reviews)

CDP Choline (Citicoline Sodium, CAS 33818-15-4)

Specification: ≥98.0% Purity (Citicoline Sodium); CAS No.: 33818-15-4; Formula: C₁₄H₂₅N₄NaO₁₁P₂
Suggested Soluble Ratio: Freely soluble in water (recommended 5%-20% aqueous solution for formulation; compatible with most polar solvents)
Appearance: White crystalline or crystalline powder; Odorless
Highlights:
- Ultra-high purity (≥98.0%) with low impurity profile
- Excellent water solubility for flexible formulation applications
- Compliant with ChP2020 standards and enterprise quality specifications
- 5%-20% Competitive Prices than Global Peers
- OEM/ODM available for capsules, tablets, powders, and functional beverage blends
- Suitable for nutraceutical, pharmaceutical, and dietary supplement applications
Certificates: ISO22000, HACCP, KOSHER, HALAL, FDA
MOQ: 1kg (supports small-batch sampling for R&D and quality validation)

Description

DESCRIPTION

Citicoline Sodium, also known as CDP Choline (CAS No.: 33818-15-4, chemical formula: C₁₄H₂₅N₄NaO₁₁P₂), is a naturally occurring nutrient and essential intermediate in phospholipid biosynthesis. As a high-purity nutraceutical ingredient, it is widely recognized for its role in supporting cognitive health and cellular function, making it a valuable addition to B2B formulations targeting health-conscious consumers.

Our Citicoline Sodium is produced through advanced synthesis and purification processes, ensuring consistent purity (≥98.0%) and minimal impurities. It meets strict quality standards aligned with ChP2020 (Chinese Pharmacopoeia) and enterprise specifications, guaranteeing reliability for pharmaceutical, nutraceutical, and dietary supplement applications. Designed exclusively for B2B partners, this ingredient offers excellent water solubility and compatibility with various formulation systems, enabling seamless integration into capsules, tablets, powdered supplements, and functional beverages. Rigorous quality control throughout the production process ensures freedom from harmful contaminants, making it a trusted choice for global brands.

Key Features

Feature	Details
Purity	≥98.0% (assayed by ChP2020 method)
Chemical Identity	Citicoline Sodium (CDP Choline), CAS 33818-15-4
Physical Form	White crystalline or crystalline powder; Odorless
Solubility	Freely soluble in water; Insoluble in ethanol and acetone
Solution Clarity	Clear, colorless aqueous solution
Impurity Control	Single impurity ≤0.2%; Total impurities ≤0.7%
Heavy Metal Limit	≤5 ppm
Endotoxin Level	<0.30 EU/mg
Quality Standards	ChP2020, enterprise standards, FDA-compliant

Proven Health Benefits

Supports healthy cognitive function and mental clarity
Contributes to the maintenance of healthy brain cell membranes
Aids in promoting optimal focus and attention
Supports healthy nervous system function
Helps maintain cellular energy metabolism
Aligns with nutraceutical trends for brain health and cognitive support

Powerful Applications

Our Citicoline Sodium is a versatile B2B ingredient for diverse formulations:

Dietary Supplements: Capsules, tablets, powdered supplements, and nootropic blends
Pharmaceutical Formulations: Nutraceuticals and prescription-grade cognitive support products
Functional Foods & Beverages: Brain-boosting drinks, fortified snacks, and energy supplements
Cosmetic & Personal Care: Topical formulations for skin barrier support (phospholipid synthesis)

Technical Specifications & Analysis

Physicochemical & Purity Specifications (ChP2020 Compliant)

Test Item	Specification	Analytical Method
Assay (Citicoline Sodium)	98.0% - 102.0% (≥98.0% minimum)	ChP2020
Description	White crystalline or crystalline powder; odorless	ChP2020
Solubility	Freely soluble in water; insoluble in ethanol and acetone	ChP2020
Solution Clarity & Color	Clear, colorless	ChP2020
Chloride	≤0.05%	ChP2020
Ammonium Salt	≤0.05%	ChP2020
Iron Salt	≤0.01%	ChP2020
Phosphate	≤0.1%	ChP2020
Related Substances (5`-CMP)	≤0.3%	ChP2020
Single Impurity	≤0.2%	ChP2020
Total Impurities	≤0.7%	ChP2020
Loss on Drying	≤6.0%	ChP2020
Heavy Metals	≤5 ppm	ChP2020
Arsenic Salt	≤0.0001%	ChP2020
Endotoxin	<0.30 EU/mg	ChP2020
Residual Solvents (Methanol)	≤0.3%	ChP2020
Residual Solvents (Ethanol)	≤0.5%	ChP2020
Residual Solvents (Acetone)	≤0.5%	ChP2020

Microbiological Specifications

Test Item	Specification	Analytical Method
Total Plate Count	≤1000 CFU/g	ChP2020
Yeast and Mold Count	≤100 CFU/g	ChP2020
Escherichia Coli (E.Coli)	Negative	ChP2020

Related Brain Health & Cognitive Support Ingredients

Product Name	Specification	Application
Alpha-GPC Powder	≥98% Purity	Cognitive support supplements, nootropic blends
L-Theanine Powder	≥99% Purity	Stress management, focus-enhancing formulations
Bacopa Monnieri Extract	≥50% Bacosides	Memory support supplements, functional beverages
Huperzine A Extract	≥98% Purity	Cognitive health nutraceuticals

Package & Storage

Standard Packaging:
- 1kg/5kg aluminum foil bags (vacuum-sealed with desiccant to prevent moisture absorption)
- 10kg/20kg/25kg paper-plastic composite drums (inner: food-grade polyethylene liner; outer: moisture-proof, opaque material for light protection)
Custom Packaging: We offer flexible solutions for small-batch R&D (e.g., 500g sample packs) or large-scale bulk orders (e.g., 500kg jumbo bags). Contact our sales team to tailor packaging to your logistics and branding needs.
Storage Guidelines: Store in a shaded, cool, dry, and well-ventilated environment. Keep tightly sealed to protect from moisture, light, and oxygen. Avoid exposure to high temperatures and strong odors.
Shelf Life: 24 months from the production date when stored under recommended conditions.

Logistics & Quality Assurance

Global B2B Shipping: We provide flexible shipping terms (DAP, DDP, FOB, CIF, CIP, CFR) with expertise in delivering to European and American pharmaceutical and nutraceutical markets. Our logistics partners ensure secure, temperature-controlled transport for sensitive ingredients.
Free R&D Samples: Complimentary samples are available for purity testing, formulation trials, and stability studies to support your product development process.
Stringent Quality Control: Each production batch undergoes pre-production raw material inspection and post-production finished product testing in compliance with ChP2020 standards. Only batches that meet our strict purity and safety criteria are approved for shipment.
Comprehensive Customs Support: We supply all necessary legal documentation for cross-border trade, including Certificate of Origin (COO), Non-GMO Statements, Allergen-free Certifications, Batch Test Reports (COA), and Safety Data Sheets (SDS).

Frequently Asked Questions (FAQ)

FAQ Questions	Answers
Does your Citicoline Sodium comply with international pharmacopoeial standards (e.g., USP, EP) in addition to ChP2020?	Yes, our product meets ChP2020 standards and is also compliant with USP and EP requirements for purity, impurities, and safety. We can provide documentation to verify compliance with specific regional standards upon request.
What is the particle size of the powder, and can it be customized for tablet or capsule formulations?	The standard particle size is optimized for flowability and dissolution (suitable for most tablets and capsules). We offer custom particle size modification (e.g., micronization) to meet your specific formulation needs—contact our technical team for details.
Is the product free from allergens, GMOs, and artificial additives?	Yes, our Citicoline Sodium is non-GMO, allergen-free (no soy, dairy, nuts, gluten, or shellfish), and contains no artificial preservatives, colors, or fillers. It is a pure, single-ingredient product.
Can you provide technical support for formulation stability and compatibility?	Absolutely. Our team of food scientists and pharmaceutical experts offers end-to-end support, including formulation compatibility testing, dissolution rate optimization, stability studies, and guidance on label claims compliance for 欧美 markets.
What is the lead time for bulk orders, and do you maintain stock for urgent requests?	Standard lead time for bulk orders (100kg+) is 10-15 working days. We maintain safety stock of standard specifications to support urgent orders (3-5 working days) for B2B partners in the pharmaceutical and nutraceutical industries.
Does the product meet the requirements for GRAS (Generally Recognized As Safe) status in the US?	Yes, our Citicoline Sodium is GRAS-compliant for use in dietary supplements and functional foods. We can provide GRAS-related documentation and safety data to support your regulatory submissions in the US and EU.
How do you ensure batch-to-batch consistency in purity and impurity profiles?	We implement a strict quality management system, including standardized synthesis processes, raw material traceability, in-process testing at key production stages, and batch-by-batch final testing of purity, impurities, and contaminants. This ensures consistent quality across all orders.

Functional Positioning and Target Users of Citicoline Sodium
Citicoline Sodium serves as a critical nutrient supplement targeting manufacturers and formulators specializing in cognitive support and neurological health products. Recognized for its role as an intermediate in phospholipid biosynthesis, this ingredient is instrumental in enhancing mental clarity and neural function. Nutritional product developers, botanical extracts companies, and pharmaceutical formulators leverage this compound for its capability to improve cognitive performance and nervous system resilience. Its purity and safety profile make it suitable for integration into capsules, tablets, powdered blends, and functional beverages designed for health-conscious consumers and therapeutic users alike.

Technical Features and Measurable Specifications
This Citicoline Sodium is characterized by an assay purity of no less than 98%, fully compliant with Chinese Pharmacopoeia 2020 standards, ensuring rigorous control over impurities including heavy metals (≤5 ppm) and endotoxins (<0.30 EU/mg). The white crystalline, odorless powder exhibits excellent water solubility, enhancing formulation flexibility across various dosage forms. Its precise chemical identity (CAS 33818-15-4) and compliance with FDA, ISO22000, HACCP, KOSHER, and HALAL certifications underpin its robust manufacturing process. Quality control parameters, including total impurities ≤0.7% and microbial limits, guarantee batch-to-batch consistency critical for reliable product performance in nutrient supplements and pharmaceutical-grade applications.

Industry Applications and Real-World Value
In the nutraceutical and pharmaceutical industries, this Citicoline Sodium is widely incorporated into cognitive enhancement formulations, providing measurable benefits for mental acuity and nervous system support. Botanical extracts companies use it as a foundational ingredient in nootropic blends and functional beverages, capitalizing on its solubility and sensory neutrality. Additionally, its compliance with international regulatory standards allows seamless integration into diverse product lines from dietary capsules to topical cosmetic formulations targeting phospholipid synthesis in skin care. This solution enables companies to meet evolving market demands for scientifically validated cognitive supplements with reproducible quality and safety.

Use Scenarios

In Nutritional Supplement Manufacturing and Formulation
Within the dietary supplement manufacturing sector, this Citicoline Sodium functions as a key ingredient for cognitive health products designed to support mental clarity and neurological function. The operational environment demands strict adherence to ingredient purity and regulatory standards, which this product satisfies through comprehensive technical specifications and certifications. Its high water solubility and lack of odor facilitate incorporation into capsules, tablets, and powders without interfering with flavor or texture profiles. Nutrient supplement developers deploy it within manufacturing workflows that require reproducible quality and compliance to maintain product efficacy and consumer trust, thereby streamlining formulation validation and approval processes.

Application in Functional Beverages and Pharmaceutical Products
In the functional beverage and pharmaceutical domains, Citicoline Sodium is incorporated to enhance cognitive benefits and nervous system support within liquid or semi-solid matrices. The botanical extracts companies and pharmaceutical formulators operating in this environment require ingredients that meet strict impurity limits and possess excellent solubility for homogeneous distribution in complex formulations. This product’s compliance with international food safety and pharmacological standards enables seamless integration into beverages and pharmaceutical-grade supplements, supporting workflow efficiency and product consistency. Its performance characteristics contribute to formulation stability and consumer safety, essential for regulatory approval and market acceptance.

FAQ

What purity standards and certifications does your Citicoline Sodium conform to?
Our Citicoline Sodium (CDP Choline) meets ultra-high purity requirements (≥98%) and complies with ChP2020, FDA, ISO22000, HACCP, KOSHER, and HALAL certifications. This ensures premium quality and safety for nutraceutical manufacturers and nutrition distributor partners.

Can you provide customized packaging and particle size for the CDP Choline product?
Yes, we offer OEM/ODM services with flexible packaging options tailored for capsules, tablets, or powders. Particle size customization is available to optimize flowability and dissolution, meeting specific formulation needs of nutrient supplements producers.

How do you ensure consistent quality and safety from batch to batch?
We implement rigorous quality control processes including third-party testing before shipment, strict impurity and heavy metal limits, and monitoring endotoxin levels. This guarantees each batch of Citicoline Sodium maintains consistent standards vital for health product formulations.

What logistics and delivery support do you provide for bulk orders?
Keep Ingredients supports fast and reliable delivery options including direct flights and sea freight with DDP terms. We provide detailed shipment documentation—COA, third-party inspection reports, and certificates—to ensure smooth customs clearance for international nutrition distributor clients.

Why Choose Us as Your Supplier?

Consistent High Purity: Our Citicoline Sodium maintains ≥98.0% purity with tight impurity control, meeting global pharmacopoeial standards for pharmaceutical and nutraceutical use.
Technical Expertise: Our team provides tailored support for formulation, regulatory compliance, and stability studies, helping you streamline product development for EU & USA markets.
Competitive Pricing: Direct manufacturing and efficient supply chain management enable us to offer 5-20% more competitive pricing than global suppliers, without compromising quality.
Flexible Supply Solutions: We support small-batch R&D orders (1kg MOQ) and large-scale bulk supply, with customizable packaging and particle size options to meet your business needs.
Full Certification Portfolio: ISO22000, HACCP, FDA, KOSHER, and HALAL certifications ensure our products meet diverse market and regulatory requirements.
24/7 B2B Customer Support: Our dedicated sales and technical teams are available around the clock to address inquiries, order updates, and after-sales support for global partners.

Contact Us for a Quote or Sample

Ready to elevate your cognitive health formulations with our high-purity Citicoline Sodium (CDP Choline, CAS 33818-15-4)?

Please note that our products and services are intended for commercial and industrial use only. Contact our sales team today to discuss your specific B2B requirements, request a free sample, or obtain a detailed quotation.

Phone: +86 13484914978
WhatsApp: +86 17396654828
Email: info@keepingredients.com