Product Name: Pantethine Powder (USP Grade / High Bioavailability Coenzyme A Precursor)
Specification: Active Content >50% (Tested at 55.6%); USP Grade Compliant; CAS No.: 138148-35-3; Molecular Weight: 554.72
Suggested Applications & Dosage: Highly soluble in water systems. Widely used in premium dietary supplements, Coenzyme A (CoA) precursor formulas, cardiovascular health formulations, and lipid-management capsules and tablets (recommended dosage should be formulated based on targeted daily intake of 300 mg to 900 mg).
Appearance: White or off-white crystalline powder/concentrate, odorless, pure quality.
Key Highlights:
High-Activity Coenzyme A Precursor: Pantethine is the biologically active disulfide form of Vitamin B5 (Pantothenic Acid). Compared to standard pantothenic acid, it offers superior bioavailability and converts directly into Coenzyme A.
USP Grade High Purity: Manufactured strictly according to United States Pharmacopeia (USP) quality standards, featuring active content >50% (batch tested at 55.6%).
Ultra-Low Heavy Metals & High Safety: Total heavy metals ≤0.3 ppm, with lead, arsenic, cadmium, mercury, and microbiological limits performing far better than industry standards.
Cardiovascular & Lipid Health Support: A highly targeted nutrient ingredient backed by clinical research, widely used to support healthy cholesterol and triglyceride levels.
Global Compliance & Reliable Service: Supported by a mature global supply chain and complete customs clearance documentation, with low MOQs (starting from 1 kg) and free sample testing for R&D.
Minimum Order Quantity (MOQ): 1 kg (Supports small-batch sampling for R&D and quality verification).
Pantethine (CAS No. 138148-35-3) is the active disulfide derivative of Vitamin B5 (Pantothenic Acid). In human metabolic pathways, pantethine serves as a key precursor for synthesizing Coenzyme A (CoA) and Acyl Carrier Protein (ACP). Compared to conventional Calcium Pantothenate, pantethine bypasses rate-limiting enzymatic conversion steps, offering significantly higher bioavailability to directly participate in lipid metabolism and cellular energy production.
Our pantethine raw material is produced in strict compliance with USP standards, boasting an active content exceeding 50% (batch tested at 55.6%) and appearing as a clean white to off-white crystalline powder. With extremely low heavy metal limits (total heavy metals ≤0.3 ppm), it is ideal for dietary supplement brands and pharmaceutical companies developing high-quality lipid management, cardiovascular care, and cellular energy formulas.
To assist formulation engineers and R&D specialists in achieving optimal stability and absorption efficiency, refer to the following guidelines:
Direct CoA Conversion: Provides a direct disulfide structure that bypasses the Pantothenate Kinase rate-limiting enzyme, making it the most direct oral route to boost intracellular CoA levels.
Excellent Water Solubility & Formulation Flexibility: Highly soluble in aqueous phases, suitable for hard capsules, softgels (oil suspension systems), tablets, and functional liquid shots.
Synergistic Blending Suggestions: Commonly combined with Red Yeast Rice, CoQ10, Plant Sterols, and Omega-3 Fish Oil to amplify synergistic effects in cardiovascular and lipid health formulas.
Recommended Daily Intake: In dietary supplement formulations, clinically studied daily dosages typically range from 300 mg to 900 mg per day (divided into 2–3 doses taken with meals).
Owing to its clear metabolic mechanism and excellent safety profile, pantethine is widely used in high-end nutritional and wellness applications:
Cardiovascular & Lipid Management Supplements: Helps maintain healthy levels of triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL).
Energy Metabolism & Anti-Fatigue Formulas: Functions as a Coenzyme A precursor to promote fatty acid beta-oxidation in the TCA cycle, enhancing cellular ATP generation.
Liver Health & Detoxification Support: Supports hepatic lipid metabolism, helps reduce fat accumulation in liver tissue, and protects antioxidant cellular barriers.
Adrenal & Stress Management: Supports the synthesis of adrenal cortical hormones, helping the body manage chronic stress and fatigue.
We adhere to stringent quality control standards to ensure every batch of Pantethine complies with international benchmarks:
Compliance Standard: Meets USP (United States Pharmacopeia) Standards.
Technical Specification:
| Test Items | Specification |
| Appearance | White or off-white crystalline powder |
| Water | ≤ 1.0% |
| Identification | IR spectrum: Consistent with reference |
| Boiling Point | 987.2 °C (760mmHg) |
| Flash Point | 550.8 °C |
| Density | 1.277 g/cm³ |
| Effective Content | > 50% |
| Molecular Weight | 554.72 |
| Heavy Metal | ≤ 0.3 ppm |
| Lead (Pb) | Passed (<5 ppm) |
| Arsenic (As) | Passed (<1 ppm) |
| Cadmium (Cd) | Passed (<5 ppm) |
| Mercury (Hg) | Passed (<1 ppm) |
| Total Aerobic Microbial Count | Conforms (<1000 cfu/g) |
As your trusted global ingredient supplier, Keep Ingredients delivers dependable supply chain services:
Rich Export Experience: Products exported to over 30 countries and regions, fully aligned with regulatory requirements in North America, Europe, and Asia.
Dedicated Freight & Smooth Logistics: Partnered with professional freight forwarders to ensure safe, prompt, and smooth delivery via ocean, air, or express.
Professional Customs Documentation: Proficient in preparing full sets of COA, TDS, MSDS, and export customs documentation for hassle-free clearance.
Flexible Orders & Free Sample Support: Low MOQ starting from 1 kg, alongside free sample delivery for laboratory testing, assay verification, and trial runs.
Q1: What is the difference between Pantethine and Pantothenic Acid (Vitamin B5)?
A1: Pantethine is the active disulfide form of Pantothenic Acid containing cysteamine. Pantothenic acid must be converted into pantethine in the human body before synthesizing Coenzyme A; thus, direct supplementation with pantethine yields higher metabolic efficiency and targeted cardiovascular benefits.
Q2: What is the shelf life and proper storage condition?
A2: Under original unopened packaging and stored in a cool, dry, well-ventilated environment away from moisture, the shelf life is 24 months.
Q3: Can we request free samples for lab quality testing?
A3: Yes, absolutely! We provide free samples for R&D and QC teams to perform HPLC assays, heavy metal testing, and formulation trials.
Q4: What packaging options are available for bulk orders?
A4: Our standard bulk packaging is 25 kg/drum with internal moisture-proof double plastic bags. Customized smaller packaging is also available for R&D customers.
Q5: Is Pantethine hygroscopic? What precautions should be taken during processing? A5: Pantethine exhibits mild hygroscopicity. We recommend weighing and capsule filling in temperature- and humidity-controlled cleanrooms (relative humidity <50%), or utilizing softgel / moisture-barrier coating processes.
Q6: Do heavy metal and microbiological limits meet European and US import standards?
A6: Yes, total heavy metals are controlled at ≤0.3 ppm, and lead, arsenic, cadmium, mercury, and microbial counts strictly meet and surpass USP and EP pharmacopeial standards.
Ready to upgrade your product line with active Coenzyme A precursor formulations?
Whether you are developing advanced cardiovascular health capsules or sourcing high-purity, low-heavy-metal USP-grade Pantethine raw material, our expert team is here to assist you!
Fast Sample Express: Need to verify purity, solubility, or heavy metal specifications in your lab? Let us know your requirements, and we will gladly send free testing samples along with complete technical documentation.
1-on-1 Technical Consultation: Have questions about dosage levels, synergistic blending, or moisture control during production? Our technical specialists are ready to help.
Seamless Worldwide Delivery: Supported by our mature export network across 30+ countries, your samples and bulk shipments will arrive safely and promptly.
Let's discuss your next project! Contact our team today to request samples, technical documents, or commercial quotes. We look forward to partnering with you!
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Email: info@keepingredients.com
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